Macrocarpa definition is a new zealand evergreen shrub or tree cupressus macrocarpa that is used for hedges and that sometimes causes abortion in cattle that browse on it. Response surface methodology rsm was employed to describe explicitly the influence of extraction time, temperature and solventtofeed ratio on the yield of oil using central composite design. Pdf extraction of mangiferin from mahkota dewa phaleria. Phytochemistry and medicinal properties of phaleria. Abstractobjectives this study was designed to investigate the effect of phaleria. For example, mahkota dewa phaleria macrocarpa is one of the herbs regularly used in traditional remedies among local folks in areas, reaching a height of around 16 metres hendra et al. The purpose of this study was to determine the effects of phaleria macrocarpa pm on male fertility by assessing its effect on the sperm characteristics which included the sperm count, motility, viability and morphology. In this study, there are four different treatment being used which are 10g. In vitro and in vivo effects of standardized extract and.
Growth performance of phaleria macrocarpa seedling using. The protective effects of phaleria macrocarpa pm against oxidative stress in diabetic rats were investigated. Antiinflammatory effect of mahkota dewa phaleria macrocarpa. International research journal of pharmaceutical and. Antioxidant, antiinflammatory and cytotoxicity of phaleria. Molecules free fulltext development of phaleria macrocarpa. Phaleria macrocarpa suppress nephropathy by increasing. Phaleria macrocarpa is a dense evergreen tree, growing well in tropical climates. Antioxidant effects of methanolic extract of phaleria macrocarpa scheff. Pdf phaleria macrocarpa, commonly known as mahkota dewa is a medicinal plant that is indigenous to indonesia and malaysia. Extraction of mangiferin from mahkota dewa phaleria macrocarpa using subcritical water. Diabetes was induced in male sprague dawley rats using alloxan 150 mgkg i. Growth performance of phaleria macrocarpa seedling. Pdf phaleria macrocarpa or mahkota dewa has been a unique plant because of its antioxidant, antiinflammatory and anticancer properties.
Phaleria macrocarpa name synonyms drimyspermum macrocarpum scheff. This article is from iranian journal of basic medical sciences, volume 17. Traditionally, phaleria macrocarpa has been used to treat impotency, control cancer, haemorrhoids, diabetes mellitus, allergies, liver and heart disease, kidney disorder, blood diseases, acne, stroke, migraine and various skin diseases. Optimization of mangiferin extrated from phaleria macrocarpa. Phaleria macrocarpa or mahkota dewa has been a unique plant because of its antioxidant, antiinflammatory and anticancer properties. From the fruits of phaleria macrocarpa, icariside c3 1, phalerin 2, and mangiferin 3 were isolated and their structures were identified on the basis of spectroscopic data. Phaleria macrocarpa buah mahkota dewa, gods crown, pau is a dense evergreen tree, indigenous to indonesia.
Measurement of blood glucose levels were performed before additon of glucose and every 30 minutes for 120 minutes after a glucose solution was added by using a glucometer. Testicular morphology of male rats exposed to phaleria. One vital therapeutic approach for the treatment of type 2 diabetes mellitus is the use of agents that can decrease postprandial hyperglycaemia by inhibiting carbohydrate digesting enzymes. The effectiveness of phaleria macrocarpa and chemotherapy. Mahkota dewa phaleria macrocarpa, a good source of saponin, flavanoid, polyphenol, alkaloid, and mangiferin has an extensive range of medicinal effects. Eighteen male rats were equally divided into three groups. Application of organic fertilizer is important to supply good nutrient source to soil and to avoid environmental pollution. The therapeutic effect of phaleria macrocarpa scheff boerl, is related to the its bioactive compounds contents. The effectiveness of phaleria macrocarpa and chemotherapy in. The effect of mahkota dewa phaleria macrocarpa scheff boerl leaf etanolic extract on splenic nk 1. The lc50 of ethyl acetate fraction of phaleria macrocarpa extract was 38.
The fresh fruit of this plant which is in the red color was cut into small pieces and let. Boerl is native plants from indonesia, which has long been used as folk medicines for treatments various types of diseases such as cancer, liver disorders, heart disease, diabetes, arthritis, kidney disorders, stroke, and high blood pressure14. Hypertension was induced experimentally by 10% wv fructose diet ad libitum for 8 weeks. Effects of the methanol extracts phaleria macrocarpa. Phaleria macrocarpa fruit were divided into pericarp, mesocarp and seed. After the administration of pm fractions for two weeks the diabetic symptoms, nephropathy and renal antioxidant enzymes were evaluated. Antioxidant effects of methanolic extract ofphaleria. The use of phaleria macrocarpa traditional medicine. Plants that are commonly used as medicine is phaleria macrocarpa known as mahkota dewa in west. The native range of the species during modern times is confined to two small relict populations near carmel, california, at cypress point in pebble beach and at point lobos.
All parts of the fruit were reflux extracted with methanol. Phaleria macrocarpa mahkota dewa is a medicinal plant found in papua, indonesia. In recent years, the utilization of certain medicinal plants as therapeutic agents has drastically increased. Boerl is native plants from indonesia, which has long been used as folk medicines for treatments various types of diseases such as cancer, liver disorders, heart disease, diabetes, arthritis, kidney disorders, stroke, and high blood pressure harmanto, 2003. Among the various environmental factors that play a dominant role in postharvest physiology of fruits and seeds, desiccation tolerance has received the widest attention for seed storage as planting materials and for germplasm conservation purposes. There was a significant effect of fruit decoction of phaleria macrocarpa to decrease the level of uric acid in elderly. Aug 10, 2016 the lc50 of ethyl acetate fraction of phaleria macrocarpa extract was 38. The potential use of phaleria macrocarpa leaves extract. Introduction blood pressure, the treatment must be adapted to the particular hypertension or high blood pressure is defined in an adult human as a blood pressure greater than or equal to 140 mmhg of systolic pressure and 90 mmhg of diastolic pressure. Leaves extract on colon carcinogenesis induced by azoxymethane and.
It is a tree with stems, leaves, roots, flowers, and fruits. The present study investigated the effects of bioassayguided extract and fractions of the dried fruit pericarp of phaleria macrocarpa, a traditional antidiabetic plant, on. The phytochemical studies of this plant have revealed the presence of bioactive compounds. Nutritional values such as ash, fiber, protein, fat, and carbohydrate contents. Effect of phaleria macrocarpa on sexual function of rats saadat parhizkar1, che zairieha binti che zainudin2, mohammad aziz dollah2 abstract objectives.
Phaleria macrocarpa fruits methanolic extract reduces blood. Phaleria macrocarpa is primarily propagated using seeds. Then measured levels of calcium, creatinine value, urea value, and histopathologic renal rat test. Each group of rats was orally supplemented for 7 weeks either with pm aqueous. Mahkota dewa pheleria macrocarpa scheff, boerl is an herbal medicine which has been used since many years as traditional medicine in. Response surface methodology rsm was employed to describe explicitly the influence of extraction time, temperature and solventtofeed ratio on the yield of oil using central composite design ccd. The effect of mahkota dewa phaleria macrocarpa scheff. Boerl thymelaceae originates from papua island, indonesia and grows in tropical areas. Phaleria macrocarpa is a traditional medicinal plant from new guinea, papua island, and indonesia. Phaleria macrocarpa, spontaneous hypertensive rats, blood glucose, blood. However, the concentration of few of its constituents in a particular fraction of p. The result shows that there was an increase in caspase 3 expression in all treatment groups which were given phaleria macrocarpa extract, paclitaxelcisplatin chemotherapy, and the combination of both. It is a complete tree, including stem, leaves, flowersand fruitsfigure1. Files are available under licenses specified on their description page.
For indonesia, fruits and leaves of phaleria macrocarpa has been used to cure various health problems, including empirical treatment for cancer. Desiccation tolerance in phaleria macrocarpa embryonic axes. The purpose of current study was to determine the effect of phaleria macrocarpa p. Mahkota dewa pheleria macrocarpa scheff, boerl is an herbal medicine which has been used since many years as traditional medicine in indonesia against infections. Join facebook to connect with phaleria macrocarpa and others you may know. Phaleria macrocarpa fruits methanolic extract reduces. Nutritional values such as ash, fiber, protein, fat, and carbohydrate contents were. Its fruit has an ellipse shape and is about 3 cm in diameter. The extracts are reported for a number of valuable medicinal properties such as anticancer, antidiabetic. Optimization of oil yield of phaleria macrocarpa seed. The results showed that ethanol extract of phaleria macrocarpa had antinephrolithiasis effect in vitro and in vivo, ie at dose 400 mgkg bw value of calcium level of 1,99 mgg was significantly different with negative control group p phaleria macrocarpa, commonly known as mahkota dewa is a medicinal plant that is indigenous to indonesia and malaysia.
Phytochemistry and medicinal properties of phaleria macrocarpa. Mahkota dewa prevents renal damage monday, 09 september 20 wib, by. Studies on the constituents from the fruits of phaleria. Phaleria capitata ongael, phaleria jack phaleria clerodendron scented daphne phaleria perottetiana. Sumatra, melastoma malabathricum known as sikaduduak and morinda citrifolia known as mengkudu. Phaleria macrocarpa used as a comparison with a dose of 14 mgkg ww. Effect of phaleria macrocarpa on sexual function of rats. Antioxidants, phytochemicals, and cytotoxicity studies on phaleria. Polyphenol compounds of mahkota dewa phaleria macrocarpa scheff. Cupressus macrocarpa, now classed as hesperocyparis macrocarpa, commonly known as monterey cypress, is a species of cypress native to the central coast of california. Molecular dynamics simulation of mahkota dewa phaleria.
Pdf phytochemistry and medicinal properties of phaleria. Mangiferin is one of the major bioactive compounds of phaleria macrocarpa. Polyphenol compounds of mahkota dewa phaleria macrocarpa. Icariside c3 1 showed a slow vasorelaxant activity against noradrenalineinduced contraction of isolated rat aorta. Formulation and evaluation of sunscreen gels containing. Aprilita rinayanti universitas esa unggul 15 publications 15 citations see profile maksum radji university of indonesia 58 publications 191 citations see profile abdul. Macrocarpa definition of macrocarpa by the free dictionary. Findings of this study showed that there was a significant difference in the mean value of the levels of uric acid before and after given fruit decoction of phaleria macrocarpa p0.
Mar 01, 2006 phaleria macrocarpa fruit were divided into pericarp, mesocarp and seed. Media in category phaleria macrocarpathe following 5 files are in this category, out of 5 total. Atoms from the trajectory files of the simulation labeled and then each pair of labeled. Desiccation tolerance in phaleria macrocarpa embryonic. Forest plantation and agroforestry abstract medicinal plant usage in traditional treatment is very important to communities in developing. It has long been used as a cure for various diseases such as cancer, liver disease, heart disease, diabetes, arthritis, kidney dis ease, stroke and hypertension. Macrocarpa definition at, a free online dictionary with pronunciation, synonyms and translation. Skin of the fruit contains alkaloids, saponins, and flavonoids. Phaleria macrocarpa, commonly known as mahkota dewa is a medicinal plant that is indigenous to indonesia and malaysia. Phaleria macrocarpa locally known as mahkota dewa is one of the important medicinal plants that originates from papua island, indonesia and grows in tropical areas. The study population was outpatients with knee oa at rheumatology clinic dr hasan sadikin hospital bandung. Methods phaleria macrocarpa fruit were divided into pericarp, mesocarp and seed.
Macrocarpa definition of macrocarpa by merriamwebster. Uji aktivitas antinefrolitiasis ekstrak etanol buah. It is found in tropical areas of new guinea up to 1,200 m 3,900 ft above sea level. God petals contain antihistamines, alkaloids, saponins, and polyphenols lignans. Effectivity and safety of mahkota dewa fruit extract. A wide variety of pachira macrocarpa options are available to you, such as tropics, glacial, and subfrigid. The present investigation was undertaken with the purpose of developing pharmacopoeial standards for this species. Files are available under licenses specified on their. Phaleria macrocarpa, the gods crown ethnobotany the. This species is primarily propagated by using seeds. Phaleria macrocarpa was obtained from skudai in johor bahru, malaysia with latitude of 216. The extracts are reported for a number of valuable medicinal properties such as anticancer, antidiabetic, antihyperlipidemic, anti.
Optimization of oil yield of phaleria macrocarpa seed using. Effects of the methanol extracts phaleria macrocarpascheff. Marwati mahkota dewa phaleria macrocarpa is a indigenous plant of indonesia. Growth performance of phaleria macrocarpa seedling using different rate of organic fertilizer cow manure name. Phaleria contain several active substances such as. Phaleria macrocarpa, commonly known as gods crown, mahkota dewa or pau is an indonesian plant of family thymelaceae that grows in tropical areas of papua island. There are many reported compounds from phaleria macrocarpa scheff boerl, which are found, reported and published such as icariside, phalerin, mangiferin, gallic acid, 29norcucurbitacin, gentiobioside and glucoside. It hails from papua and normally planted as shrubs or decorative plants. The antioxidant activity of the extracts were characterized in various in vitro model systems such as ftc, tba, dpph radical, reducing power and no radical. The record derives from tropicos data supplied on 20120418 which reports it as an accepted name record 50315226 with original publication details. Effect of phaleria macrocarpa on sperm characteristics in.
Phaleria macrocarpa mahkota dewa seed was examined to determine the optimal conditions of oil yield by solvent extraction method using nhexane as extracting solvent. The intermolecular interactions between solute and solvents such as hydrogen bonding considered. This research is to investigate anticancer mechanism of phaleria macrocarpa fruits extracts ebmd in nf. Phaleria macrocarpa is a popular medicinal plant in indonesia and has recently been introduced in malaysia in view of its commercial potential as health supplement.
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